Researchers Successfully Reverse Alzheimer’s in Mice: Peer-Reviewed Study

 A recent study published on December 22 in the journal Cell Reports Medicine reported significant progress in reversing Alzheimer's disease in mice. This breakthrough could provide new avenues for treating the disease in humans.

• Researchers used a treatment called P7C3-A20 on two groups of genetically modified mice that exhibited Alzheimer’s-like symptoms.

• The treatment improved brain cell energy balance by restoring Nicotinamide adenine dinucleotide (NAD+) levels, crucial for brain function.

• It also reversed brain damage, oxidative stress, neuroinflammation, and restored the blood-brain barrier's integrity.

• The mice displayed full cognitive recovery and reduced levels of p-tau217, a biomarker for Alzheimer’s.

• Starting the treatment in younger mice led to restored brain health after six months.

• Researchers believe this approach challenges previously held views that Alzheimer's is irreversible and may pave the way for new therapies.

The study shows that, under specific conditions, the damaged brain can repair itself. Given the rising number of Alzheimer’s patients, these findings are seen as a hopeful message, suggesting that advanced research and clinical tests could lead to effective treatments for humans. 

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