Reactivation of the varicella-zoster virus, which causes herpes zoster in humans, can be a rare adverse reaction to vaccines.
The aim of this study was to assess whether the frequency of HZ is found to increase after COVID-19 vaccination in a large cohort, based on real-world data.
Each cohort accounted for 1 095 086 patients.
For the vaccinated group, 2204 subjects developed HZ within 60 days of COVID-19 vaccination, while among Cohort II, 1223 patients were diagnosed with HZ within 60 days after having visited the clinic for any other reason.
The risk of developing shingles was calculated as 0.20% and 0.11% for cohort I and cohort II, respectively.
Consistent with the hypothesis, a higher incidence of HZ was statistically detectable post-COVID-19 vaccine.
Even though the molecular basis of VZV reactivation remains murky, temporary compromising of VZV-specific T-cell-mediated immunity may play a mechanistic role in post-vaccination pathogenesis of HZ. Note that VZV reactivation is a well-established phenomenon both with infections and with other vaccines.
No comments:
Post a Comment