The Worst Atrocity In The History Of The World Has Been Confirmed

 We will test our models of host range experimentally using reverse genetics, pseudovirus and receptor binding assays, and virus infection experiments in cell culture and humanized mice.

The year 2 report clearly states that AIM 3 for year 3 had been expanded to also include conducting gain-of-function research using the MERS virus!

Using the S sequence of different MERS-related viruses identified from Chinese bats, the chimeric viruses with S gene of bat MERS-related coronaviruses and backbone of the infectious clone of MERS-CoV will be constructed to study the receptor usage and infectivity of bat MERS-related coronavirus.

If these numbers are correct, this would be a case fatality rate of 31%! MERS-CoV did not appear to be highly infectious, unlike SARS-CoV-2-WIV. Note that the above passage includes references to creating new chimeric variants and linking them to the infectivity of MERS! Could you imagine if they also created a more highly infectious MERS virus, that they spread through out the world, like SARS-CoV-2-WIV? The devastation would be like nothing the world has ever seen.

To assess the usage of human ACE2 by the three novel SL-CoVs, we conducted virus infectivity studies using Hela cells with or without the expression of human ACE2.

Mice were infected with 105 pfu of full-length recombinant virus of WIV1and the three chimeric viruses with different spikes.

3.3 Virus characterization: 3.3.a Construction of chimeric SARSr-CoV viruses: Infectious clones with the S gene of novel SARSr-CoVs and the SARSr-CoV WIV1 genome backbone using the reverse genetic system developed in our previous R01. The correct infectious BAC clones will be screened by BAC DNA digestion with appropriate restriction enzyme or PCR amplification.

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